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Mitochondrial complex I defects in aging

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5a), approved for the treatment of amyotrophic lateral sclerosis, increases ROS levels by multiple mechanisms, including decreasing LDH-A and NAD + levels to increase oxidative stress, as well as interfering with the xCT antiporter to block the cystineglutamate pump

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And sometimes we think about what I call the total body burden

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Three months of multimodal training contributes to mobility and executive function in elderly individuals with mild cognitive impairment, but not in those with Alzheimers disease: a randomized controlled trial

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