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Pollizzi KN, Patel CH, Sun IH, Oh MH, Waickman AT, Wen J, et al

Recently, genetically modified hematopoietic stem cells for ex vivo gene therapy have been tested as an alternative option and are expected to eventually become standard treatment for X-ALD

While 12 weeks of bright light exposure did not produce measurable improvements in sleep quality, glucose metabolism, or inflammatory markers, it significantly altered clock gene expression in peripheral blood mononuclear cells (PBMCs, specifically decreasing REV-ERB levels and increasing the REV-ERB/BMAL1 ratio)