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3326-A TARGETING PKM2 IN NASH-HCC: CROSS TALK BETWEEN HEPATIC MACROPHAGE REGULATION AND TGF-BETA SIGNALING Kazufumi Ohshiro 1 , Krishanu Bhowmick 1 , Xiaochun Yang 2 , Dillon Voss 3 , Adrian R Krainer 3 and Lopa Mishra 1,3 , (1)The Institute for Bioelectronic Medicine, Feinstein Institutes for Medical Research, & Cold Spring Harbor Laboratory, Department of Medicine, Division of Gastroenterology and Hepatology, Northwell Health, Manhasset, New York, USA., (2)The Institute for Bioelectronic Medicine, Feinstein Institutes for Medical Research & Cold Spring Harbor Laboratory, Department of Medicine, Division of Gastroenterology and Hepatology, Northwell Health, NY, USA., (3)Cancer Center, Cold Spring Harbor Laboratory, NY, USA

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The main component of vinegar is acetic acid derived from fermentation giving vinegar its distinctive taste and pungent smell (Budak et al., 2014)

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