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This is what atherosclerosis in our head looks like: clogged with cholesterol, closing off our arteries, clamping down on blood flow

First, mechanistic studies should integrate single-cell transcriptomics and spatial metabolomics to map cell-type-specific ferroptosis pathways in hippocampal and cortical neurons and microglia, with particular focus on the link between NCOA4-mediated ferritinophagy and A clearance, thereby building a dynamic model connecting iron dysregulation, proteotoxic stress, and cell death

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