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186 Similarly, lactate from patient-derived GSCs and microglia/macrophages triggers histone Kla, boosting transcriptional upregulation of CD47 in GBM cells, ultimately suppressing phagocytosis and inducing immunosuppressive programs

Glutathione deficiency has been linked to: - Age-related diseases such as Alzheimer's and Parkinson's - Coronary and autoimmune diseases - Arthritis, asthma and other inflammatory conditions - Cancer - Mitochondrial Dysfunction - Muscle weakness and fatigue HEALTH BENEFITS OF GLUTATHIONE Glutathione against oxidative stress Glutathione reduces the amount of reactive oxygen species (ROS) and the damage caused by oxidative stress in cells and DNA

Indeed, blocking the recruitment of these cells into the CNS provides significant neuroprotection in preclinical PD models [28]