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49 One of the underlying mechanisms of ROS-mediated tubulointerstitial injury is the exposure of tubular cells to LDL, which may result in tubulointerstitial damage due to NADPH oxidase-mediated ROS production

Conclusions In summary, our data show that in vitro cuprizone directly increases BBB permeability mediated by downregulation of tight junction proteins

Methods The proteins encoded by the methylenetetrahydrofolate reductase ( MTHFR ) and glutathione S-transferase omega-1 ( GSTO-1 ) genes are, through oxidative mechanisms, key participants in the cerebral response to ischemia

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