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Starting with modified furan leads to direct dual-functionalisation of oligonucleotides Showing the broad applicability of this methodology by functionalising eight different primary amine-bearing oligomers (phosphodiester-, phosphorothioate- or peptidic backbone, LNA modifications, internal amines and different terminal amines), we next evaluated the single-site one-step dual-functionalisation of AONs

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Tretinoin is prescription-strength retinoic acid: faster and more powerful than over-the-counter retinol, but with more dryness, peeling, and sun sensitivity