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The first DNMT (DNMT1) was discovered in 1988 [40], followed by DNMT3a and DNMT3b in 1998 [41]

List of abbreviations ALOX5 Arachidonate 5-lipoxygenase ALT Alanine Transaminase AMPK Adenosine Monophosphate-Activated Protein Kinase AKT Protein kinase B BDNF Brain-derived neurotrophic factor CAT Catalase CB1/CB2 Cannabinoid 1/2 CDKs Cyclin-dependent kinases COX Cyclooxygenase EI Electron Ionization ERK 1/2 Extracellular signal-regulated kinase 1/2 GC-MS Gas Chromatography- Mass Spectroscopy GDNF Glial cell line-derived neurotrophic factor GPx Glutathione peroxidase GSH Glutathione GST Glutathione S-transferases H 2 O 2 Hydrogen Peroxide HDAC Histone Deacetylase HETES Hydroxyeicosatetraenoic acids HMC3 Human Microglial Clone 3 1 HNMR Proton Nuclear Magnetic Resonance HPLC High-performance Liquid Chromatography IB Inhibitor of nuclear factor-B IKK Inhibitory-B kinase IR Infrared JAK/STAT Janus kinase/signal transducers and activators of transcription JNK c-Jun N-terminal kinase LC 50 Lethal Concentration 50 LOX Lipooxygenase MDA Malondialdehyde MPO Myeloperoxidase NF-B Nuclear Factor kappa B NIH-3T3 Mouse Embryonic Fibroblast Cell line NMDA N-methyl-D-aspartate NO Nitric oxide Nrf 2 Nuclear factor erythroid 2-related factor 2 6-OHDA 6-hydroxydopamine p38 MAPK p38 mitogen-activated protein kinase pAkt Protein kinase B PLA 2 Phospholipase A 2 PKA Protein kinase A SOD Superoxide dismutase PTGS2 Prostaglandin-Endoperoxide Synthase 2 THP-1 Human Leukemia Monocyte Cell line TNF- Tumor Necrosis Factor alpha TRB3 Tribbles homolog 3 UV Ultraviolet 1

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NCOA4 plays an important role in the pathogenesis of emphysema in COPD by polarizing M2 macrophages and inducing the secretion of inflammatory cells in bronchial epithelial cells (84)