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A Japanese study noted an increase of LSS symptoms with age, observing it in 1.9% of 40 to 49 year olds, 4.8% of 50 to 59 year olds, 5.5% of 60 to 69 year olds, and in 10.8% of those aged 70 to 79

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Evidence revealed that endogenous and exogenous IGF-1 administration protects against the onset and progression of diabetic cardiomyopathy [278, 279]