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Oral administration of metformin (an AMPK activator) reduces airway inflammation and decreases pulmonary eosinophil counts in ovalbumin-induced obese allergic mice[46, 60, 106]

Wang QJ, Sun H, Dong QL, Sun TY, Jin ZX, Hao YJ, Yao YX.The enhancement of tolerance to salt and cold stresses by modifying the redox state and salicylic acid content via the cytosolic malate dehydrogenase gene in transgenic apple plants.Plant Biotechnology Journal.2016;14:1986-1997 91

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SPECT/MRI dual-modality imaging based on Mb@ 177 Lu/Gd-NTs can not only clearly show the anatomical location of tumors, but can also quantitatively display the drug biodistribution in real time, which is helpful to determine the administration time of external beam irradiation