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Beuming T et al (2008): The binding sites for cocaine and dopamine in the dopamine transporter overlap

Iron limitation inhibits iron-sulfur cluster-dependent protein lipoylation, causing the loss and inactivation of the LAT1 subunit of pyruvate dehydrogenase, thereby promoting glucose flow to the pentose phosphate pathway to increase NADPH production, and inducing non-PDH pathways such as the pyruvate bypass and fatty acid oxidation to synthesize acetyl coenzyme A, thereby maintaining survival in an iron-limited environment (Garg et al., 2025)