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Mutations in PDI and ERp57 were also described in ALS patients, but are thought to be more of a risk factor than directly causative of neurodegeneration (Woehlbier et al., 2016)

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Encouraging preclinical studies have demonstrated the potential of combining antibodydrug conjugates (ADCs) with gene-based strategies and STING agonists, paving the way for innovative approaches in the development of STING agonist therapies [272]