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Description

The best-described S6K1 target is S6 (ribosomal protein S6), although the function of its phosphorylation is still unclear, with some studies reporting that S6 phosphorylation is required for translation of ribosomal genes (Chauvin et al., 2014), whereas others showing that non-phosphorylatable S6 mutants have no effects on translation (Ruvinsky et al., 2005)