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One unit of CAT activity is defined as the quantity of enzyme required to reduce 1 M H 2 O 2 per minute

As a critical chromatin mark, the resulting H2AX scaffolds mediators like p53-binding protein 1 (53BP1) to amplify the damage signal and recruit repair factors, thereby ensuring the precise coordination of the DDR [27]

The increased apoptosis was related to the activation of p53 and p21, the decrease of the Bcl-2/Bax ratio, and the increase of caspase-3 and phosphorylated c-Jun N-terminal kinase (p-JNK) activity