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miR-542-3p/5p can inhibit the expression of 12S ribosomal RNA, thereby enhancing Transforming Growth Factor Beta 1 (TGF-1) signaling, which indicates mitochondrial ribosomal stress (Figure 2)

Selye (13) articulated the concept of stress as the nonspecific response of the body to any demand, while a stressor was considered as an agent that induces stress at any given time. Birds are vulnerable to various stressors, including environmental stressors (heat and cold stress, light, air quality, and humidity), management stressors (litter quality, stocking density, poor ventilation, beak trimming, vaccination, transportation, and handling), nutritional stressors (nutrient deficiencies, feed contamination, and mycotoxins), and biological or internal stressors such as diseases and gut microbiota imbalances (14)

During the early incubation phase, the air sac is chosen as the injection site (263)

In particular, the mitochondrial inner membrane is impermeable to fatty acyl-CoA thioesters and, thus, the specialized CS, for transporting fatty acids across mitochondrial membranes has evolved 18