l-carnitine hormone supplementation at doses of 2–4 g/day has been shown in a randomized, double-blind, placebo-controlled trial by Salvatore Benvenga to reverse and prevent symptoms of iatrogenic hyperthyroidism in women receiving TSH-suppressive levothyroxine PCOS Nutrition Center L-Carnitine Subscription

The catabolic transsulfuration pathway converts homocysteine to cysteine via two vitamin B 6 -dependent enzymes: cystathionine synthase catalyzes the condensation of homocysteine with serine to form cystathionine, and cystathionine lyase converts cystathionine to cysteine, -ketobutyrate, and ammonia

This enzyme metabolizes some dietary ingredients, such as choline, and other choline-containing compounds (phosphatidylcholine/lecithin, phosphocholine, sphingomyelin, etc .), betaine, and L-carnitine and its metabolite -butyrobetaine (GBB), releasing TMA after the cleavage of the carbon (C)nitrogen (N) bond of choline/carnitine (Zhu et al., 2014)

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There are 3 moderate contraindications