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Metformin, the only biguanide medication currently available for the treatment of diabetes, is considered the first-line drug for type 2 diabetes (Misbin 2004

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Bruker Nano GmbH, Berlin, Germany), an ion chromatograph (Shimadzu, Japan), and the Kjeldahl method, as outlined by Yoshida et al

However, the results are random, due to the wide heterogeneity, form of presentation and variability of the pathogenic mechanisms of the disease (Johnson et al., 2012)