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Axel has contributed significantly include quantitative perfusion imaging (with both computed tomography and MRI), velocity imaging, surface coil imaging, and magnetization tagging for regional cardiac function quantification

While these can help with surface-level brightness and antioxidant protection, they often struggle to penetrate deep enough into the skin to affect melanin production at the source

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Periodic, objective monitoring of medication response is critical because patients may not obtain desired pain reduction, adverse effects are common, and serious adverse effects can occur