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FIGURE 4 Neurological abnormalities are a core feature of SZ even at the time of their first episode of psychosis without antipsychotic drug treatment (Rubin et al., 1994

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Medrano JV, Hervs D, Vilanova-Prez T et al (2021) Histologic Analysis of Testes from Prepubertal Patients Treated with Chemotherapy Associates Impaired Germ Cell Counts with Cumulative Doses of Cyclophosphamide, Ifosfamide, Cytarabine, and Asparaginase

The ototoxicity of aminoglycoside drugs is associated with a higher concentration of the drug in the internal lymph fluid, which impairs the energy production and utilization of the OHCs and causes dysfunction of Na + -K + -ATPase on the cell membrane, resulting in damage to HCs