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Notably, it increases the risk for the development of heart failure [221, 222]

Similarly, NK cell cytotoxicity and proliferation critically depend on argininedepletion downregulates activating receptors (NKp46/NKp30), NK chain expression, and IFN- secretion (269)

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This combination is particularly interesting for aging-related tissue deterioration, where both mitochondrial dysfunction and impaired repair signaling contribute to declining tissue health