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Often described as tingling, prickling, or sunburn-like sensitivity

In the current study, ARA 290 significantly improved the total score compared with the placebo group

10.1021/bk-2024-1465.ch001 22

Key copper-dependent enzymes include: Superoxide Dismutase (SOD1): Antioxidant defense Cytochrome c Oxidase: Mitochondrial respiration Lysyl Oxidase: Collagen cross-linking Ceruloplasmin: Iron metabolism Matrix Remodeling & Collagen Synthesis One of the most extensively studied properties of GHK-Cu is its ability to influence extracellular matrix dynamics