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HFD impairs liver glutathione biosynthesis, vitamin D metabolism genes and genes associated with non-alcoholic fatty liver disease (NAFLD) Genes involved in the GSH biosynthesis pathway were significantly downregulated in the livers of mice fed an HFD compared to those of mice fed a healthy diet (controls) (Fig

Severe depletion of GSH in the Arabidopsis mutant rml1 has been reported to result in growth inhibition and it has been speculated that this effect may be caused by severe oxidation of cytosolic E GSH and redox-dependent inhibition of the cell cycle (Vernoux et al., 2000)

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This agrees with previous studies in lungs for a half-life extended IgG1 variant in non-human primates 24,37