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Biological Chemistry 301, 108062

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Specifically, 2-O-methylation stabilizes helical regions [139, 140] and shifts the sugar pucker equilibrium toward the 3-endo conformation, which increases the overall rigidity of RNA duplexes [141, 142]

Structural modelling of MPP-PINK1 and MPP disease mutations To further rationalize our HDX-MS results and attempt to explore how PINK1 1-45 might trap MPP dimers, we generated AlphaFold3 models of MPP in complex with either PINK1 1-45 or MDH 1-24 and mapped the HDX-MS % incorporation at 5 min on these structures to identify plausible binding modes (Fig S7A)