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Additionally, studies have shown that gram-negative bacteria/LPS can induce the production of TLR4-dependent CXCL1 in hepatocytes, which induces CXCR2 + PMN-MDSCs infiltrating in TME, thereby regulating the formation of an immunosuppressive microenvironment in hepatocytes and promoting liver tumor growth [736]

Opioid analgesics like morphine activate -opioid receptors which can trigger pro-survival signaling in heart and also reduce sympathetic tone (lowering metabolic demand)

It can be stored in the refrigerator for up to 5 days or frozen for several months

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