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also corroborated these findings by comparing the effectiveness of several RTK inhibitors and antibody treatments in mouse models [97]

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Simultaneously, the mechanical properties of the ECM change significantly: the shear stiffness of the human nucleus pulposus increases from 12.5 kPa in Pfirrmann grade 116.5 kPa in grade V (Walter et al., 2017), collagen fibers thicken and become disorganized (Wuertz et al., 2007) (Table 1)

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