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The post-marketing reports of hepatitis and cholestatic jaundice in patients receiving duloxetine emerged in late 2005

However, consumption of dietary AGEs from sources such as fructose- or sucrose-enriched diets and/or soft drinks can worsen liver fibrosis faster than consumption of endogenous AGEs

An enhanced comprehension of oxidative stress mechanisms, coupled with the emergence of innovative therapeutic strategiesincluding the development of antioxidant enzyme activators, the utilization of nanotechnology to facilitate drug delivery, and the modulation of Nrf2 and PI3K/Akt signaling pathwaysoffers novel strategies and methodologies for addressing CNS diseases

Whether alterations in metabolism drive secondary injury processes or simply result from the subsequent depletion of cellular energy stores and oxidative stress is less clear