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A 2008 study on muscle endurance and power in college varsity football players showed essentially no such benefit, while a small trial in cross-country runners three years later found no performance-enhancing benefits and one result that actually contradicted the claim made for the patch

J Biol Chem 273:32377

Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, Ferguson KC, Heller J, Platt DM, Pasquinelli AA, Liu LX, Doberstein SK, Ruvkun G (2001) Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C

While these are not systemic therapies, they represent a growing use case within anti-aging and facial aesthetics