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The synchrony between excitatory pyramidal Delay cells, which produce the necessary persistent neuronal activity, and fastspiking GABAergic neurotransmission, which in turn shape and finetunes the pyramidal cell output, underlies working memory

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Although small-molecule PHGDH inhibitors effectively suppress tumor proliferation in preclinical models [52, 53], their therapeutic index may be limited by the essential physiological role of de novo serine synthesis in the central nervous system [54]

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