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Springer International Publishing, Cham, pp 265273

The small molecule therapy crosses the blood-brain barrier and has showed efficacy against glioblastomas, including those resistant to the standard of care temozolomide ( TABLE 1 Current FDA Trials involving ONC201 (clinicaltrials.gov)

MOTS-c activates AMPK pathways that improve GLUT4 glucose transport, restoring cellular glucose uptake without the GI side effects of metformin.5 For adults managing prediabetes or metabolic syndrome, this is clinically significant