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Future in vitro studies to test candidate therapeutic compound in COVID-19 should deploy standardized assays, for example, Vero cells that can competently replicate and isolate the virus readily, whereas in vivo studies should utilize transgenic mice and Syrian hamsters, or cats and ferrets if opting for larger experimental animals

What's the level of proof that they're going to require

Spasmolytic and uroprotective effects of apigenin by downregulation of TGF- and iNOS pathways and upregulation of antioxidant mechanisms: in vitro and in silico analysis

Discussion In this study, we developed a small compound, termed JMF4073, which inhibits CMPK and TMPK