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Vitamin K-dependent proteins such as osteocalcin and matrix Gla protein are crucial to many physiological processes such as bone mineralization, vascular calcification, and cardiovascular health

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In the tumor microenvironment, macrophages frequently exhibiting DNA damage promote immune escape by secreting immunosuppressive factors such as IL-10 and TGF-, whereas during aging, persistent DNA damage in macrophages alters their secretory phenotype, fostering chronic inflammatory conditions in tissues (Fig

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