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Graphical Abstract Access this article Similar content being viewed by others References Shellard E, Houghton P, Resha M (1978) The Mitragyna species of Asia

Rather than forcing cells to behave differently, it upregulates the growth factors and signaling pathways that are already part of the natural healing cascade VEGF for blood vessel formation, ERK1/2 for cell proliferation, and collagen deposition pathways for structural repair