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Chronic studies in rats given 200 mg/kg body weight per day for 104 weeks, dogs given 20 mg/kg PO x 84 days, cats given 40-65 mg/kg for 118 days did not produce any signs of toxicity (blood testing, liver histology)

Contrarily, PGE2 fosters adipogenesis in white fat tissue and induces glycogenolysis and gluconeogenesis, thus alleviating insulin resistance of adipocytes

In vivo Glutathione, oxidized is reduced back to GSH via the NADPH-dependent enzyme glutathione reductase

The nanoparticles engineered to cross the BBB can precisely deliver neuroprotective agents to affected regions of the brain, thereby minimizing the widely observed side effects to enhance the therapeutic efficacy of the drug (Naqvi et al., 2020)