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Brazil nuts are a rich source of selenium, and a regular intake has been shown to significantly increase the activity of the GPx1 enzyme in C allele carriers

Some prodrugs require specific enzymes or endogenous compounds for hydrolysis, such as the carboxylesterases including acetylcholinesterase, butyrylcholinesterase and arylesterase that are critically involved in the bioconversion of ester-based prodrugs into pharmacologically active forms ( 5.4 Combination drug therapy Combination therapies aim to improve curcumin bioavailability by inhibiting its inactivation and metabolism

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Some studies suggest better oral bioavailability compared to reduced glutathione, though research specifically examining liver outcomes is sparse