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Infect Disord Drug Targets 20(1):1626 Luangmonkong T et al (2018) Targeting oxidative stress for the treatment of liver fibrosis

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461,462,463,464 Notably, recent studies further support the pivotal role of NRF2 in intracellular metabolic reprogramming during hepatocyte proliferation, demonstrating its involvement in promoting glycolysis, nucleic acid synthesis, the oxidative pentose phosphate pathway (PPP), and NAD + /NADH synthesis, while downregulating OXPHOS