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A deficiency in B12 is one of the most common causes of peripheral neuropathy, a condition characterised by tingling, numbness, burning sensations, or weakness in the hands and feet

However, the largest Phase IIb trial involving 536 subjects failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading Metabolic Pharmaceuticals to terminate development in 2007

Decrease dose if: Experiencing consistent side effects (headaches, fatigue, GI disturbance), achieving satisfactory results at current dose with no need for escalation, or cost considerations favor using minimum effective dose

Fatigue: Some participants reported fatigue or tiredness during treatment periods