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This finding indicates the potential importance of ghrelin in the early stages of tumorigenesis ( Furthermore, the initial identification of ghrelin expression in esophageal squamous cell carcinoma was achieved through immunohistochemistry, wherein tissue ghrelin levels exhibited significant associations with the extent of differentiation, level of tumor invasion, lymph-vascular invasion, and tumor stage ( 8 Conclusion and prospects In conclusion, this review provides a comprehensive overview of the association between ghrelin and GI disorders

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