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If soil is lacking Se, crops subsequently grown in that soil and used for feedstuffs will also be Se deficient [6]

The Sestrins have been shown to interact with GTPase-activating protein toward rags 2 (GATOR2), leading to the inhibition of mTORC1 activity [27]

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So, thats just one example of how just the lack of rigor and the lack of communication between the published research and the current standard of care and statistics is not serving us and likely hugely underestimates the already dramatically high rates of nutrient insufficiency