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J Immunol 155:21232133 Fowlkes JL, Serra DM, Bunn RC et al (2004) Regulation of insulin-like growth factor (IGF)-I action by matrix metalloproteinase-3 involves selective disruption of IGF-I/IGF-binding protein-3 complexes

What happens right after I do something that is really pleasurable, she says, and releases a lot of dopamine is, again, my brain is going to immediately compensate by downregulating my own dopamine receptors And thats that comedown, or the hangover or that aftereffect, that moment of wanting to do it more. Someone who waits for the feeling to pass, she explained, will reregulate, go back to baseline

doi: 10.3109/17435390.2015.1071443 74 AlfarhanMWAl-HussainiHKilarkajeN

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