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doi: 10.1002/mnfr.201501017

In vivo toxicity of GNCsiRNA Free siRNA duplexes are potent to activate the mammalian innate immune system, and lead to systemic inflammation in vivo through inducing high levels of inflammatory cytokines 45,46 , thus the inflammatory responses by siRNA can result in significant toxicities in vivo

It is generally believed that host defense mechanisms are mediated by such strong effects that pharmacological antioxidants would not be able to overcome the powerful oxidant effects