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On the other hand, cancer cells sometimes exploit a reversible inactivation of GAPDH via oxidative modification of its active-site cysteine (a GAPDH redox switch), which diverts glucose flux into the pentose phosphate pathway to generate NADPH for antioxidant defense 114

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After the first dose of the two-shot Moderna regimen, 87 percent of people under 65 years old and 74 percent of those 65 and up in clinical trials reported localized pain, echoing research that shows a decline in immune reactivity with age