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Importantly, RRM2 is often found overexpressed in NB, and its depletion was shown to induce G1/S phase arrest due to replicative stress and checkpoint kinase 1 (CHK1) activation (47, 48)

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Yet, Tesamorelin also has an acetyl group (CHCO-) attached to the N-terminus, which may potentially enhance the stability and observed activity of the peptide