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The number of days since the patient began psychiatric treatment was negatively correlated with the frequency of experiencing poor appetite ( r = 0.093, p = 0.018), but not with insomnia (r = 0.071, p = 0.073), end-of-dose crash ( r = 0.004, p = 0.923), or return of symptoms ( r = 0.009, p = 0.823)

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No repeated dihexa administration does not alter the pharmacokinetic half life because the peptide is fully metabolized and excreted between doses, preventing accumulation

The compound has been the subject of extensive preclinical research, particularly in models studying tissue repair, angiogenesis, and gastrointestinal mucosal integrity