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In addition, kynurenine reduces the cytotoxicity of NK cells by inhibiting NK cell-activating receptors NKp46 and NKG2D 39

[16] 2 Both the apo (PDB id: 3N6W) [17] and the holo (PDB id: 3O2G) [18] structures of gamma-butyrobetaine dioxygenase have been solved, demonstrating an induced fit mechanism may contribute to the catalytic activity of gamma-butyrobetaine dioxygenase