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A study that shows a reduction in histone-deacetylase activity in alveolar macrophages from cigarette smokers, which could explain the poor anti-inflammatory effects of corticosteroids in COPD

Gahl WA, Dalakas MC, Charnas L, Chen KT, Pezeshkpour GH, Kuwabara T, Davis SL, Chesney RW, Fink J, Hutchison HT (1988) Myopathy and cystine storage in muscles in a patient with nephropathic cystinosis