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Administracin de cidos nucleicos que codifican polipptidos de FX modificados (terapia gnica) 3

Its possible to boost glutathione levels through supplementation, diet, and lifestyle changes

For example, the modified FX polypeptide is a modified zymogen FX containing substitution (s) of amino acids in a zymogen FX polypeptide containing a light chain having at least 80%, 85%, 86%, 87%, 88 %, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or more sequence identity with the zymogen FX light chain polypeptide has the sequence of amino acids 1-139 of SEQ ID NO: 134 and / or a heavy chain having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or more sequence identity with the zymogen FX heavy chain polypeptide having the amino acid sequence 143-448 of the SEQ ID NO: 134 Examples of said modified zymogen FX polypeptides are FX polypeptides containing a light chain having amino acid sequence 1-139 shown in ID NO: 134 (ie, corresponding to amino acids 1-139 of any of SEQ ID NOS

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