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This can result in an enlarged spleen, which can cause abdominal pain and tenderness

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Intranasal delivery, used with Selank and Semax, bypasses first-pass enzymatic metabolism in some systems, which partially explains why researchers observe longer effective durations than the IV values listed in typical half-life reference data

These techniques, however, are subject to the limited supply of donor corneas, risk of graft rejection, post-operative complications associated with sutures and wound healing, risk of corneal neovascularization and/or infection, high astigmatism after suture removal, need for long-term immunosuppression and necessity for long-term patient follow-up 20