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In the MOXIe study, alanine and aspartate aminotransferase (ALT and AST) elevations were among the most common treatment-emergent adverse events (TEAEs) in the omaveloxolone arm and were mild to moderate, generally asymptomatic, transient, and reversible

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In the following sections, we will discuss how oxidative stress may affect endothelial function with a particular focus on the so far identified ROS sources that are relevant to hypertension