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CLDN1 mAbs strongly inhibited migration and invasion in cell-based models and lung metastasis formation in vivo , suggesting a key role of CLDN1 in tumor metastasis

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SSc-related fibrosis SSc, a heterogeneous, autoimmune connective tissue disease, is induced by the massive proliferation of fibroblasts and excessive ECM synthesis, which causes scar tissue to replace the physiological structure of blood vessels, skin and internal organs

The twin announcements underscore M+C Saatchi Performance's increasing investment in Indonesia, where its Jakarta operation has grown to more than 100 employees, making it one of the agency's fastest-growing offices in the Asia Pacific region