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0.277 between Pharmavista and MediQ and 0.131 for the three databases), echoing earlier findings by Amkreutz et al., with a concordance coefficient of 0.23 [95% CI 0.11, 0.35] between Pharmavista and MediQ for DDIs focusing on immunosuppressants (Shariff et al., 2021)

This process consumes significant energy and substances, and the inflammatory mediators entering the circulation act as new signaling molecules, inducing further inflammation throughout the body